Some of the different drugs that can potentially interact with Provigil in a negative way include seizure medications like Phenobarbital, antidepressants like doxepin and imipramine, and MAO inhibitors like selegiline and phenelzine. This drug has proven to be extremely effective in treating narcolepsy as well as other sleep disorders that can cause sudden drowsiness, though it does not affect everyone in the same way. Your doctor will adjust your dosage of this medication accordingly, but it is important to manage your expectations when starting out. Provigil is FDA approved, but there are still certain side-effects that can come with taking it.